By Ashutosh Tiwari, Bora Garipcan, Lokman Uzun
The booklet outlines first the significance of additional mobile Matrix (ECM), that is a traditional floor for many of cells. within the following chapters the impression of organic, chemical, mechanical, and actual houses of surfaces in micro and nano-scale on stem telephone habit are mentioned together with the mechanotransduction. Biomimetic and bioinspired ways are highlighted for constructing microenvironment of numerous tissues, and floor engineering purposes are mentioned in tissue engineering, regenerative drugs and diversified form of biomaterials in quite a few chapters of the book.
This booklet brings jointly leading edge methodologies and techniques followed within the learn and improvement of Advanced Surfaces in Stem cellphone Research. famous around the world researchers planned matters including:
- Extracellular matrix proteins for stem mobilephone fate
- The superficial mechanical and actual homes of matrix microenvironment as stem mobilephone destiny regulator
- Effects of mechanotransduction on stem mobilephone behavior
- Modulation of stem cells habit via bioactive surfaces
- Influence of managed micro and nanoengineered surfaces on stem cellphone fate
- Nanostructured polymeric surfaces for stem cells
- Laser floor amendment recommendations and stem cells applications
- Plasma polymer deposition: a flexible device for stem cellphone research
- Application of bioreactor suggestion and modeling options in bone regeneration and augmentation treatments
- Substrates and surfaces for regulate of pluripotent stem phone destiny and function
- Application of biopolymer-based, floor changed units in transplant drugs and tissue engineering
- Silk as a ordinary biopolymer for tissue engineering
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Additional info for Advanced Surfaces for Stem Cell Research
R. Stem cells and their niches. Science 311, 1880–5, 2006. 2. , et al. Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes & Development 28, 1085–100, 2014. 3. , Di Girolamo N. Limbal epithelial stem cells: role of the niche microenvironment. Stem Cells 30, 100–7, 2012. 4. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677–89, 2006. 5. , Théry C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12, 1659–68, 2011.
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3 Illustration on the effect of aspect ratio on platelet adhesion. (a) The bending movements of the high-aspect-ratio flexible pillars prevent the platelets from making a successful contact on the topographic surfaces compared to (b) the low-aspect-ratio pillars where they remain stiff and upright in liquid media even under agitation, thereby permitting platelet attachment at a greater ease. Dimensions are not drawn to scale. Adapted from Koh et al. . The Superficial Mechanical and Physical Properties 31 Increased interspacing to dimension >200 nm results in the entrapment of platelets and its subsequent activation due to increased surface area of contact and entrapment, Increased aspect ratio in submicron structures reduces the number of adherent platelets due to the inability of the platelets to form stable contacts with the reduced surface area for attachment.
Advanced Surfaces for Stem Cell Research by Ashutosh Tiwari, Bora Garipcan, Lokman Uzun