By Ewold W Dijk, Ben L. Feringa, Gerard Roelfes (auth.), Thomas R. Ward (eds.)
In order to fulfill the ever-increasing calls for for enantiopure compounds, heteroge- ous, homogeneous and enzymatic catalysis advanced independently some time past. even if all 3 methods have yielded industrially achievable methods, the latter are the main commonplace and will be considered as complementary in lots of respects. regardless of the development in structural, computational and mechanistic stories, besides the fact that, thus far there's no common recipe for the optimization of catalytic methods. therefore, a trial-and-error technique continues to be primary in catalyst discovery and optimization. With the purpose of complementing the well-established fields of homogeneous and enzymatic catalysis, organocatalysis and synthetic metalloenzymes have loved a contemporary revival. man made metalloenzymes, that are the point of interest of this ebook, outcome from comb- ing an energetic yet unselective organometallic moiety with a macromolecular host. Kaiser and Whitesides recommended the potential of growing synthetic metallo- zymes as in the past because the overdue Seventies. although, there has been a frequent trust that proteins and organometallic catalysts have been incompatible with one another. This critically hampered learn during this quarter on the interface among homogeneous and enzymatic catalysis. seeing that 2000, even though, there was a turning out to be curiosity within the box of synthetic metalloenzymes for enantioselective catalysis. the present cutting-edge and the possibility of destiny improvement are p- sented in 5 well-balanced chapters. G. Roelfes, B. Feringa et al. summarize examine hoping on DNA as a macromolecular host for enantioselective catalysis.
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Extra resources for Bio-inspired catalysts
Five iron atoms are accommodated at one of the nucleation sites and [4Fe–3O] clusters are created using glutamic acid (Fig. 7b). Sadler et al. have shown multinuclear Hf and Zr clusters formed in a ferric-ionbinding protein, Fbp [10, 19]. The crystal structure of Fbp containing Hf atoms shows that three types of Hf clusters are formed by utilizing a di-tyrosyl cluster nucleation motif (Tyr195-Tyr196) in an interdomain cleft. Two types of trinuclear clusters and one pentanuclear oxo-Hf cluster are generated at this site (Fig.
The specific interactions such as hydrogen bonding with Lys96 and His97 are also observed (Fig. 3a). The composite showed higher peroxidase and peroxygenase activities than native Mb due to stronger coordination of iron porphycene to His93 than that of heme. Crystal structures of a series of metal Schiff base complexes in the apo-Mb cavity have been determined by Watanabe et al. [16, 17]. , planar four coordinate ligands and the use of proximal histidine as an axial ligand (Figs. 3b and Fig. 4) [16, 17].
29. 30. 31. 32. 33. Lu Y (2006) Angew Chem Int Ed 45:5588–5601 Steinreiber J, Ward TR (2008) Coord Chem Rev 252:751–766 Thomas CM, Ward TR (2005) Chem Soc Rev 34:337–346 Uchida M, Klem MT, Allen M, Suci P, Flenniken M, Gillitzer E, Varpness Z, Liepold LO, Young M, Douglas T (2007) Adv Mater 19:1025–1042 Ueno T, Abe S, Yokoi N, Watanabe Y (2007) Coord Chem Rev 251:2717 Ueno T, Yokoi N, Abe S, Watanabe Y (2007) J Inorg Biochem 101:1667 Akabori S, Sakurai S, Izumi Y, Fujii Y (1956) Nature 178:323–324 Wilson ME, Whitesides GM (1978) J Am Chem Soc 100:306–307 Abe S, Ueno T, Reddy PAN, Okazaki S, Hikage T, Suzuki A, Yamane T, Nakajima H, Watanabe Y (2007) Inorg Chem 46:5137–5139 Alexeev D, Zhu HZ, Guo ML, Zhong WQ, Hunter DJB, Yang WP, Campopiano DJ, Sadler PJ (2003) Nat Struct Biol 10:297–302 Calderone V, Casini A, Mangani S, Messori L, Orioli PL (2006) Angew Chem Int Ed 45:1267–1269 Debreczeni JE, Bullock AN, Atilla GE, Williams DS, Bregman H, Knapp S, Meggers E (2006) Angew Chem Int Ed 45:1580–1585 Hu YZ, Tsukiji S, Shinkai S, Oishi S, Hamachi I (2000) J Am Chem Soc 122:241–253 McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang FY, Walkinshaw MD, Sadler PJ (2004) Chem Commun 2004:1786–1787 Satake Y, Abe S, Okazaki S, Ban N, Hikage T, Ueno T, Nakajima H, Suzuki A, Yamane T, Nishiyama H, Watanabe Y (2007) Organometallics 26:4904–4908 Ueno T, Ohashi M, Kono M, Kondo K, Suzuki A, Yamane T, Watanabe Y (2004) Inorg Chem 43:2852–2858 Ueno T, Koshiyama T, Ohashi M, Kondo K, Kono M, Suzuki A, Yamane T, Watanabe Y (2005) J Am Chem Soc 127:6556–6562 Ueno T, Yokoi N, Unno M, Matsui T, Tokita Y, Yamada M, Ikeda-Saito M, Nakajima H, Watanabe Y (2006) Proc Natl Acad Sci USA 103:9416–9421 Zhong WQ, Alexeev D, Harvey I, Guo ML, Hunter DJB, Zhu HZ, Campopiano DJ, Sadler PJ (2004) Angew Chem Int Ed 43:5914–5918 Zunszain PA, Ghuman J, Komatsu T, Tsuchida E, Curry S (2003) BMC Struct Biol 3:6–14 Hayashi T, Hitomi Y, Ando T, Mizutani T, Hisaeda Y, Kitagawa S, Ogoshi H (1999) J Am Chem Soc 121:7747–7750 Hayashi T, Murata D, Makino M, Sugimoto H, Matsuo T, Sato H, Shiro Y, Hisaeda Y (2006) Inorg Chem 45:10530–10536 Carey JR, Ma SK, Pfister TD, Garner DK, Kim HK, Abramite JA, Wang Z, Guo Z, Lu Y (2004) J Am Chem Soc 126:10812–10813 Ohashi M, Koshiyama T, Ueno T, Yanase M, Fujii H, Watanabe Y (2003) Angew Chem Int Ed 42:1005–1008 Collot J, Gradinaru J, Humbert N, Skander M, Zocchi A, Ward TR (2003) J Am Chem Soc 125:9030–9031 Letondor C, Humbert N, Ward TR (2005) Proc Natl Acad Sci USA 102:4683–4687 Komatsu T, Ohmichi N, Zunszain PA, Curry S, Tsuchida E (2004) J Am Chem Soc 126:14304–14305 Mahammed A, Gross Z (2005) J Am Chem Soc 127:2883–2887 Marchetti M, Mangano G, Paganelli S, Botteghi C (2000) Tetrahedron Lett 41:3717–3720 Reetz MT, Jiao N (2006) Angew Chem Int Ed 45:2416–2419 Hunter TM, McNae IW, Liang XY, Bella J, Parsons S, Walkinshaw MD, Sadler PJ (2005) Proc Natl Acad Sci USA 102:2288–2292 Aime S, Frullano L, Crich SG (2002) Angew Chem Int Ed 41:1017–1019 Ishii D, Kinbara K, Ishida Y, Ishii N, Okochi M, Yohda M, Aida T (2003) Nature 423:628–632 42 S.
Bio-inspired catalysts by Ewold W Dijk, Ben L. Feringa, Gerard Roelfes (auth.), Thomas R. Ward (eds.)