By Albert Segaloff (auth.), William L. McGuire M.D. (eds.)
Breast melanoma remains to be the focal point of extreme simple and scientific study. In Valurne 1 of this sequence we dealt solely with subject matters thinking about treatment. within the current Valurne 2, we flip our consciousness to the experimental biology that's the root for our comprehend ing of difficulties excited about breast melanoma etiology, mechanisms of hormone motion, mobile kinetics, experimental chemotherapy, and markers of tumor burden. The participants to the quantity are all famous students who're for my part investigating those difficulties. the 1st bankruptcy addresses the query, do hormones reason breast melanoma? Segaloff offers us with a rational up to date evaluation of the prevailing info. He concludes that hormones through themselves should not tumor initiators yet fairly adjust the hast surroundings in order that different cancer causing agents are powerful. lt is mentioned that the choice of the modeltest method is necessary; it is easy to virtually guarantee any wanted end result via settling on an ap propriately biased try procedure. The query of the function of viruses within the etiology of human breast melanoma continues to be unanswered regardless of based reports in mause systems.
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Additional info for Breast Cancer:Advances in Research and Treatment, Vol. 2: Experimental Biology
Competition curves of incompletely cross-reacting proteins will plateau at some Ievel above complete displacement of labeled antigen. The first category of reactivity is characteristic of a group-specific reaction, while the latter two can be designated as type-specific reactions. We setout to determine whether both type and group specificities are associated with the 52,000-dalton major envelope glycoprotein (gp52) of MMTV virions. 2. <8·9·25> By all these criteria, no evidence of type-C retroviruses was detected in any of the MMTV preparations used.
10. C. Huggins, L. C. Grand, and F. P. Brillantes, Mammary cancer induced by a single feeding of polynuclear hydrocarbons and its suppression, Nature (London) 189, 204-207 (1961). 11. A. C. Andersen, Parameters of mammary gland tumors in aging beagles, J. Am. Vet. Med. Assoc. 147, 1653-1654 (1965). 12. R. Tyslowitz and E. arge doses of estrogens on the blood picture of dogs, Endocrinology 29, 817-827 (1941). 13. R. Hili and K. Dumas, The use of dogs for studies of toxicity of contraceptive hormones, in: Pharmacological Models in Contraceptive Developments, p.
Moreover, we recently demonstrated< 8•9 > that this method allows the production of MMTV from all mouse strains examined. These include mammary tumors of strains C3H, RIII, GR, DD, BALB/cfC3H, and BALB/c. These cultures have been extensively examined by a variety of criteria to demonstrate the purity of MMTV produced, and have been shown to contain little or no contaminating type-C murine leukemia virus or other adventitious viruses. Furthermore, these cultures are an excellent source of both MMTV 60-70 S RNAs and radioactive MMTV cDNAs (DNAs complementary to the RNA of the MMTVs).
Breast Cancer:Advances in Research and Treatment, Vol. 2: Experimental Biology by Albert Segaloff (auth.), William L. McGuire M.D. (eds.)