By Jonathan Gillard, Dr Martin Graves, Thomas Hatsukami, Chun Yuan
Stroke is a massive reason behind morbidity and mortality, with carotid disorder representing an enormous contributory probability issue. This publication bargains finished assurance of the pathogenesis and administration of carotid sickness with particular specialise in the function imaging has to play within the early attractiveness of symptomatic and asymptomatic affliction in addition to the therapy of the constructed . Technological advances in imaging modalities now enable distinctive research of the ailment development, the prediction of serious occasions resulting in a stroke, in addition to the identity of the best surgical or different interventional remedies. This e-book will be learn by way of neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists interested by the care of sufferers with carotid disorder, and likewise by way of researchers concerned with the advance of recent healing concepts and drugs.Stroke is an important explanation for morbidity and mortality, with carotid sickness representing a huge contributory chance issue. This e-book deals accomplished insurance of the pathogenesis and administration of carotid affliction with particular specialise in the function imaging has to play within the early attractiveness of symptomatic and asymptomatic illness in addition to the therapy of the built situation. It discusses the technological advances in imaging modalities which now permit specified research of the sickness development, the prediction of severe occasions resulting in a stroke, in addition to the id of the best surgical or different interventional remedies. hugely illustrated all through with best specialist participants, this publication may be learn through neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists serious about the care of sufferers with carotid illness, and likewise through researchers concerned with the advance of latest healing concepts and medicine.
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Extra resources for Carotid Disease: The Role of Imaging in Diagnosis and Management
Of these patients, approximately half were symptomatic with neurologic symptoms and half were asymptomatic. 0007). In recurrent disease, the myointimal hyperplasia consisted of smooth muscle cells in a proteoglycan matrix interspersed with fibrin; the collagen and elastin representing organization of the thrombus is sparse. Neovascularity may be present but is usually not extensive and surface thrombi tend to be platelet rich. Evidence of surface thrombosis was found in 77% of cases but intraplaque thrombi are uncommon; only 15% are found in specimens collected <36 months post the initial endarterectomy.
2002). , 2002). , 2004). , 2005). Thus, there are generally consistent associations of CRP with measures of carotid atherosclerosis but associations are not always noted to be independent of other risk factors. Since CRP is a nonspecific marker, other markers of inflammation, such as interleukin (IL)-6, may prove to be more sensitive markers of carotid IMT. A number of other novel risk markers have also been examined in relation with measures of carotid atherosclerosis. Levels of circulating homocysteine have been reported to be associated with carotid stenosis and IMT.
Rosenberg, I. , et al. (1999). Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: the Framingham Study. Annals of Internal Medicine, 131, 352À5. Burke, A. , Malcom, G. , et al. (1997). Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. New England Journal of Medicine, 336, 1276À82. Burke, A. , Kolodgie, F. , et al. (2001). Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression.
Carotid Disease: The Role of Imaging in Diagnosis and Management by Jonathan Gillard, Dr Martin Graves, Thomas Hatsukami, Chun Yuan