Get Clinical and Genetic Aspects of Epilepsy PDF

By Z. Afawi

ISBN-10: 953307700X

ISBN-13: 9789533077000

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1988). These findings support the idea of dynamic CYP regulation at the blood-brain barrier by AED exposure. In general, regulation of CYPs at the blood-brain barrier could be independent from that in the liver. Support for this comes from studies in alcoholics. , 2010; Miksys & Tyndale, 2004). , 2010). Nuclear receptors that act as transcription factors control regulation of CYPs and ABC transporters in the CNS. , 2004). For example, Dauchy et al. , 2008). , 2010). This idea is supported by the fact that metabolites of CYP2J2, which is expressed in brain endothelial cells in epilepsy, activate the nuclear receptors PPAR-α (NR1C1) and PPAR-γ (NR1C3).

Wang H, Pullambhatla M, Guilarte TR, Mease RC, Pomper MG (2009) Synthesis of [(125)I]iodoDPA-713: a new probe for imaging inflammation. Biochem Biophys Res Commun 389:80-83. Wang YS, White TD (1999) The bacterial endotoxin lipopolysaccharide causes rapid inappropriate excitation in rat cortex. J Neurochem 72:652-660. Werhahn KJ, Landvogt C, Klimpe S, Buchholz HG, Yakushev I, Siessmeier T, Muller-Forell W, Piel M, Rosch F, Glaser M, Schreckenberger M, Bartenstein P (2006) Decreased 22 Clinical and Genetic Aspects of Epilepsy dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study.

However, it is currently not known if these SLC transporters can handle AEDs. An interesting blood-brain barrier transporter is the large neutral amino acid transporter LAT that transports the amino acids valine, leucine, isoleucine, tryptophan, and tyrosine. , 2008). , 1995). Whether LATs are affected in epilepsy is unknown. , 2011). Seven of these transporters belong to the ABC (ATP-binding cassette) transporter family and include Pglycoprotein (P-gp, MDR1, ABCB1), the multidrug resistance proteins 1, 2, 3, 4, and 5 (MRPs, ABCC1-5) and breast cancer resistance protein (BCRP, ABCG2).

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Clinical and Genetic Aspects of Epilepsy by Z. Afawi


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