Clinical Hepatology: Principles and Practice of - download pdf or read online

By Henryk Dancygier

ISBN-10: 3540938419

ISBN-13: 9783540938415

Clinical Hepatology – ideas and perform of Hepatobiliary ailments presents transparent and accomplished assurance of the etiology, mechanisms of illness, analysis, and sensible administration of the total spectrum of liver and biliary problems. It additionally gives an exceptional, evidence-based overview of the quickly increasing box of hepatobiliary diseases.

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Additional resources for Clinical Hepatology: Principles and Practice of Hepatobiliary Diseases

Sample text

It corresponds to approximately 15% of the hepatocyte membrane surface. Foldings of the cell membrane at the apical pole of two to three neighbouring hepatocytes demarcate a highly specialized space, the bile canaliculus. In the threedimensional reconstruction the canaliculi surround the waist of the hepatocytes in a belt-like fashion. The pericanalicular ectoplasm represents a narrow cytoplasmic zone devoid of cell organelles, but containing contractile microfilaments. The canalicular surface is isolated from the remainder of the lateral membrane by tight junctions, desmosomes and gap junctions (Fig.

Lysosomes are involved in auto- and heterophagia. g. lipofuscin. These can stay for a long time inside the hepatocyte giving rise to so-called residual bodies. g. iron as ferritin • Uptake of clathrin-coated vesicles after receptor mediated endocytosis forming endosomes. Insulin, low density lipoproteins, transferrin, immune globulin A, and asialo-glycoproteins are internalized in this manner (see Chapter 5). Fusion of endosomes leads to the formation of multivesicular bodies. 2–1 mm in diameter [96, 106].

These are regions of dense RNAcontaining granules and fibrils embedded in a protein matrix. The nuclear contents are kept separate from the cytoplasm by a nuclear membrane. This doublemembrane contains pores which allow macromolecules to cross in a two-way process. The outer sheet of the nuclear membrane is studded with ribosomes. The space between the inner and outer membrane (perinuclear space) is in straight continuity with the rough endoplasmic reticulum. The inner membrane (lamina nuclearis) consists mainly of a scaffold-like network of protein filaments.

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Clinical Hepatology: Principles and Practice of Hepatobiliary Diseases by Henryk Dancygier


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