By John W. Blunt, Murray H. G. Munro
Pushed by means of the great, but mostly unexplored, capability of bioactive organisms within the ocean and enhancements in analytical innovations to facilitate their study, average items scientists face an expanding want for single-source reference cataloging the present wisdom and state-of-the-science relating to marine typical items.
Dictionary of Marine typical items with CD-ROM provides a entire source for greater than 25,000 recognized usual items drawn from marine organisms. Following an analogous layout to the Chapman and corridor Chemical Database, this dictionary indexes every one product via chemical identify, CAS registry quantity, and compound kind. Documenting all recognized marine usual items, each one access contains the organic resource, chemical constitution, actual homes, organic task, and literature references for every compound. An accompanying CD-ROM is absolutely textual content and structure-searchable and permits specific entry to this important source. The editors, John Blunt and Murray Munro, either pioneers within the box, additionally supply an introductory monograph that describes structural compound kinds and marine organisms.
Marine organisms provide a fragile, but abundant resource for an unlimited array of novel items whose particular structural gains cause them to appropriate drug applicants, insecticides, marine anti-fouling brokers, and extra. The
Dictionary of Marine traditional items net model supplies researchers a brand new instrument for constructing pharmaceutical and chemical purposes of marine typical items.
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Additional resources for Dictionary of Marine Natural Products with CD-ROM
Et al, Progress in the Chemistry of Organic Natural Products, (eds. Hertz, W. K. et al , Nat. Prod. , 1997, 14, 163 Á189 (rev ) Carbohydr. X. et al , Nat. Prod. D. et al , The Lipid Handbook with CD-ROM , 3rd edn, Chapman & Hall/CRC Press, Boca Raton, 2007 2. POLYKETIDES (VC) Many organisms have the ability to produce a very wide range of structural types of metabolite which are derived from a poly-b-ketomethylene chain. This chain is formed by condensation of an acetyl unit (or other acyl unit) with malonyl or methylmalonyl units, with concomitant decarboxylation as in fatty acid biosynthesis but without the reduction of the intermediate b-dicarbonyl system.
8 Nucleosides (VE9900) These are glycosides of purines, pyrimidines and other heterocyclic bases. The well-known quartet of Adenosine, Guanosine, Cytidine and Thymidine are fundamental biomolecules essential to life through their participation in the structure of DNA and RNA. A number of ‘hypermodified’ nucleosides occur in bacterial nucleic acids. Another group of nucleosides consist of a sugar linked to a base either via a ring nitrogen or through a ring C atom (the latter are designated C -nucleosides).
Et al , Nat. Prod. 3 Macrolides and lactone polyketides (VC0100, VC0150) Structurally, macrolides are a class of complex lactones; normally containing a 12 Á16 membered macrocyclic ring, often with ether bridges forming further 3-, 4-, 5-, or 6-membered rings, and one to three neutral or aminosugar residues that are linked to the macrocycle via ether linkages. Examples in this class are the Bryostatins, Amphidinolides, Macrolactins, Oscillatoxins and Halichoblelide. , Macrolide Antibiotics, Chemistry, Biology and Practice, Academic Press, London, 1984 (general ) Paterson, I.
Dictionary of Marine Natural Products with CD-ROM by John W. Blunt, Murray H. G. Munro