Read e-book online Disease Markers: Cancer Genomics PDF

By Robert L. Strausberg

ISBN-10: 0585458782

ISBN-13: 9780585458786

ISBN-10: 1586032518

ISBN-13: 9781586032517

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Additional info for Disease Markers: Cancer Genomics

Example text

WT1 on the other hand has far fewer alternatives but which are of extreme importance to the malignant process. 1. CD44 The CD44 gene generates a family of molecules consisting of many isoforms [15]. CD44 proteins are single chain molecules comprising an N-terminal extracellular domain, a membrane proximal region, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is glycosylated. CD44 is the principal hyaluronic acid (HA) receptor, although the molecule can bind other ligands, in some cases with low affinity.

But large-scale omic studies of cellular molecules in aggregate rarely can answer interesting questions without the assistance of information from traditional hypothesis-driven research. The two types of science are synergistic. A case in point is the set of pharmacogenomic studies that we and our collaborators have done with the 60 human cancer cell lines of the National Cancer Institute's drug discovery program. Those cells (the NCI60) have been characterized pharmacologically with respect to their sensitivity to > 70,000 chemical compounds.

N. Weinstein et al. / Searching for pharmacogenomic markers: The synergy between omic and hypothesis-driven research 83 7. Organizing the literature on gene-gene and gene-drug correlations: MedMiner and EDGAR Fig. 4. Illustration of the principle of the clustered image map (CIM) for compact representation of high-dimensional data. Red in this case indicates high gene expression; blue indicates low expression. The clustering of like with like on both axes brings out pattern. ) See [13,14,28,33,35].

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Disease Markers: Cancer Genomics by Robert L. Strausberg


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