By Clifford F. Hawkins (Auth.)
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Extra resources for Diseases of the Alimentary Tract
Some patients are sent home to die, but reappear some years later in good health. Peptic ulcer in children The fact that peptic ulcers are somewhat rare in children has not prevented the collection of large series of cases (Sandweiss et al, 1939; Muggia and Spiro, 1959). From these studies it appears that the clinical picture, particularly in the youngest age groups, is different from that in adults, and it is therefore advisable to consider it at different ages: 1. Neonatal cases Melaena in new-born infants is often due to peptic ulceration, the acute ulcer being usually in the duodenum.
In 300 patients with stomal ulcer, 60-3 per cent were in group O (Doll, Swynnerton and Newell, 1960) in contrast to the normal frequency of about 10 per cent of the population. About 75 per cent of normals secrete in their body fluids, especially saliva and gastric juice, antigens having specificity for A, Β and Η blood group factors, and these are absent in the rest; the Η substance is present in the tissues of people of all groups and group O secretors secrete Η only. The secretion of these antigenic substances is a simple inherited difference, secretion being dominant to non-secretion.
The person with the strongest predisposition to develop duodenal ulcer is a group O non-secretor and is more than twice as liable to this disease as anyone who is a secretor in group A, Β or AB. The association between group O and peptic ulcer is not strong though the possibility of a clinical sub-group where specific substances are more marked cannot be excluded and the liability to stomal ulcer is of particular interest. It seems unlikely that blood group substances have any direct role either in causing or protecting against disease, though these blood group genes may also control the type of gastric mucosa which one inherits.
Diseases of the Alimentary Tract by Clifford F. Hawkins (Auth.)