Gene Action: Historical Account by Werner Maas PDF

By Werner Maas

ISBN-10: 0195141318

ISBN-13: 9780195141313

This is often the single e-book written by means of an individual operating within the box that offers with the heritage of gene motion. As a school pupil, Werner Maas took a path in genetics in 1941 and puzzled why so little used to be acknowledged in regards to the biochemical motion of genes in controlling the categorical functionality of an organism. simply at the moment, biochemists and geneticists started to examine together the root of gene motion, in particular in microorganisms. therefore, Maas was once in a position to witness firsthand the awesome advancements that led within the subsequent twenty-five years to a transparent photograph of the motion of genes. The background of those awesome discoveries is the center of this booklet. After 1965, construction on insights received from the paintings with microorganisms, experiences of gene motion grew to become to animals and crops and targeting techniques no longer found in microorganisms, resembling embryonic improvement, the position of genes in ailments, and the functionality of the worried approach. end result of the rapidity of technical advances made in dealing with genes, it's been attainable to benefit a lot approximately those complicated tactics. The final a part of the ebook bargains with those advancements, that are ongoing elements of the background of gene motion.

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Later, in 1924, when a stain became available, called the Feulgen stain, that gave a color with thymus nucleic acid but not with yeast nucleic acid, the division between plant and animal nucleic acid was shown to be erroneous. They were renamed ribonucleic acid (RNA) and deoxyribonucleic (DNA) acid on the basis of their sugar component. It was shown that RNA and DNA were present in both animal tissues and plant tissues; DNA was in the nucleus and RNA was in the cytoplasm. At the same time Einar Hammersten in Sweden used a very gentle method for isolating nucleic acids and found that the molecules isolated by him were much larger than the previously isolated molecules and, in fact, the postulated tetranucleotide molecules.

Wilson. He had also read Wilsons book, The Cell in Development and Inheritance, which was the bible for biologists interested in cell structures. After his graduation, Muller wanted to join Morgan's laboratory immediately but had to wait 2 years before a place became available. During these 2 years he worked at several places, but kept in close touch with Morgan's work through frequent visits and discussions. From the beginning the work of Morgan and his students was very successful. Morgan had by then demonstrated, by mating experiments, the association of several mutations with the X chromosome.

A very direct demonstration of a gene controlling the production of an enzyme occurred at the same time as Cuenot's studies on mice. The work was not that of a geneticist but of a physician. He became interested in certain rare metabolic aberrations that he encountered in his medical practice. The physician's name was Archibald Garrod. He was born in 1858, the son of Alfred Garrod, a distinguished clinician and a pioneer in the application of chemistry to medicine. A major contribution of the elder Garrod was the demonstration of high levels of uric acid in patients with gout.

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Gene Action: Historical Account by Werner Maas

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