By Seng-Lai Tan
Hepatitis C is well-known as some of the most very important new ailments afflicting guy. the invention, prognosis and preliminary remedies of hepatitis C virus (HCV) an infection are all ideal examples of the expanding influence molecular biology is at present having on sickness administration in the course of the globe. either the depth and breadth of HCV learn are becoming at a outstanding velocity and interesting new discoveries have gotten nearly common. This publication discusses the latest facets of HCV an infection, replication and molecular biology. The authors assessment the present country of growth in HCV molecular biology and talk about the questions which are at the moment dealing with molecular investigators. The chapters supply in-depth stories of the main severe components of HCV molecular study at the present time.
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Ultrastructural observations of viral particles within hepatitis C virusinfected human B lymphoblastoid cell line. Res Virol 148, 153-159. , Valli, M. , and Carloni, G. (2003). Suggested role of the Golgi apparatus and endoplasmic reticulum for crucial sites of hepatitis C virus replication in human lymphoblastoid cells infected in vitro. J Med Virol 70, 31-41. Shi, S. , Lee, K. , Hwang, S. , and Lai, M. M. (2003). Hepatitis C virus RNA replication occurs on a detergent-resistant membrane that cofractionates with caveolin-2.
2003). Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J Biol Chem 278, 41003-41012. , and Cosset, F. L. (2003a). Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J Exp Med 197, 633-642. , Pawlotsky, J. , and Cosset, F. L. (2005). An interplay between hypervariable region 1 of the hepatitis C virus E2 glycoprotein, the scavenger receptor BI, and high-density lipoprotein promotes both enhancement of infection and protection against neutralizing antibodies.
And Bolognesi, M. (2001). CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. EMBO J 20, 12-18. Klein, K. , Dellos, S. , and Lingappa, J. R. (2005). Identiﬁcation of residues in the hepatitis C virus core protein that are critical for capsid assembly in a cell-free system. J Virol 79, 6814-6826. Klein, K. , Polyak, S. , and Lingappa, J. R. (2004). Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly. J Virol 78, 9257-9269.
Hepatitis C Viruses by Seng-Lai Tan