In vivo MR techniques in drug discovery and development - download pdf or read online

By Nicolau Beckman

ISBN-10: 0849330262

ISBN-13: 9780849330261

Imaging applied sciences are receiving a lot cognizance within the pharmaceutical as a result of their strength for accelerating drug discovery and improvement. Magnetic Resonance (MR) Imaging is without doubt one of the relevant modalities because it permits anatomical, practical, metabolic, and to a undeniable quantity even target-related info to be collected in vivo at excessive solution, favoring the characterization of a ailment kingdom and the corresponding drug intervention. The non-invasiveness of MR strengthens the hyperlink among preclinical and medical pharmaceutical examine, contributing to enhance the characterization of compound results in early levels of the invention approach as a way to raise the possibilities of good fortune in later levels of drug improvement. Edited by way of a number one researcher in MR expertise, with contributions from finest specialists in academia and the pharmaceutical undefined, this name illustrates using MR thoughts during the drug discovery and improvement procedure, from goal identity and validation to medical reports. quite a few chapters specialise in person disorder parts, together with neurological, cardiac, and pulmonary issues, melanoma experiences, diabetes, arthritis, stable organ transplantation, and stem cell-based cures, displaying that various imaging suggestions are wanted for particular organs.

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7. Concluding Remarks............................................................................................................... 23 References....................................................................................................................................... 1 INTRODUCTION As seen in the previous chapter, development of new drugs requires large amounts of time and resources. Drug development is a formidable undertaking requiring nearly US$ 800 million and 12 years to bring the average drug to market commercialization [1,2].

Only then may they be applied for noninvasive testing of novel drug candidate compounds. It should be borne in mind that in animal experimentation, MR methods are in competition with established, highly developed analysis tools. In pharmaceutical research, only MR applications that offer substantial advantages over existing approaches will be successful in the long term. It is the task of imaging researchers to demonstrate to their colleagues in the pharmacological laboratories the advantages and, whenever applicable, superiority of noninvasive imaging readouts.

In the following section, we will discuss the use of MR techniques in drug research, which is the focus of our attention in this book. 3 BENEFITS AND LIMITATIONS OF MRI/S The principal assets of MRI are noninvasiveness, high spatial resolution, of the order of 100 mm for rodent studies, and excellent soft tissue contrasting capabilities. , proton density, relaxation times (T1, T2, T2p), proton exchange rates, water diffusion, macroscopic motion (blood flow), which depend on the biophysical properties of the tissue.

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In vivo MR techniques in drug discovery and development by Nicolau Beckman


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