By James Cressee Elphinstone Underwood MD, FRCPath (auth.)
Preface to the second one variation when you consider that booklet of the 1st variation, carrying on with advancements in histopathology have encouraged the inclusion of 4 new chapters: cytology, immunohistology, qc and evaluate, and the post-mortem. The expanding use of cytology in scientific perform and advances in recommendations and diagnostic interpretation justify the devotion of more room than previously to this crucial subject. Immunohistology now advantages a separate bankruptcy since it has a standing past that of being simply one other "special stain" and there are particular points of procedure and interpretation which are ordinary to it. qc and review in histopathology are very topical and critical now that higher awareness is being paid to price effectiveness and the auditing of many elements of medical perform. The post-mortem is an essential component of the pro lifetime of a histopathologist and, even though it lacks the instant scientific influence of the biopsy analysis, it however constitutes a huge job in all hospitals; with no detailing dissection suggestions i've got supplied a few info and suggestions in regards to the post-mortem which i think can be worthwhile to trainees and of curiosity to others. the rest of the publication has been completely revised and up to date, and illustrations and tables extra the place event has proven that the textual content is inadequate. Sheffield, October 1986 J. C. E. Underwood Preface to the 1st version This ebook is basically addressed to the wishes of the trainee histopathologist.
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Additional info for Introduction to Biopsy Interpretation and Surgical Pathology
A consistent sampling method must be strictly adhered to when attempts are made to determine the incidence of occult neoplastic or preneoplastic disease accurately, as has been done for occult primary carcinomas of the thyroid (Silverberg and Vidone 1966) and prostate (Franks 1954). In routine diagnostic practice it is often impractical to sample a specimen as extensively as one would when following a research protocol. An acceptable compromise as to the minimum number of blocks and sections must be decided upon.
8). In a large study (Gallagher and Martin 1969),2371 breast tissue samples were examined and, after examination by routine pathological methods, 1659 were deemed to be free from carcinoma. Radiographic examination of these tentatively benign biopsies revealed focal microcalcification in 375; this had not been noted on previous routine histology in 183 instances. Additional tissue from these cases disclosed I I ductal or lobular carcinomas that were otherwise occult. Routine breast biopsy radiography would be a formidable burden for many laboratories, but should certainly be done when initial sampling fails to reveal a lesion that has been picked up on mammography.
Information and Magnification The examination of tissues by histology is the chief diagnostic method of the histopathologist, but interpretation does not necessarily become either easier or more accurate with increasing magnification. A common misconception among trainees is that the diagnosis that seems elusive at the light microscope will always be easier 34 Macroscopy, Microscopy and Sampling at the electron microscope. Examination of a biopsy or surgical specimen at different magnifications gives, in fact, quite different sorts of information.
Introduction to Biopsy Interpretation and Surgical Pathology by James Cressee Elphinstone Underwood MD, FRCPath (auth.)