Douglas S. Johnson, Jie Jack Li's Modern Drug Synthesis PDF

By Douglas S. Johnson, Jie Jack Li

ISBN-10: 0470525835

ISBN-13: 9780470525838

Following Contemporary Drug Synthesis and The artwork of Drug Synthesis (Wiley, 2004 and 2007), well-received works, is that this new booklet that demystifies the method of recent drug discovery for practitioners and scholars. An more suitable advent covers components akin to history, pharmacology, SAR, PK/PD, efficacy, and protection. targeting the benefits of approach synthesis as opposed to the invention man made direction, glossy Drug Synthesis positive aspects authoritative assurance through wonderful editors and authors (some bankruptcy authors are the particular inventor of the drug) of twenty assorted drug molecules.

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". .. i've got no doubts that this article will be the benchmark for destiny courses at the topic, and a truly difficult act to stick with for authors making plans books in their personal in this purple scorching subject. "
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12. 13. 14. 15. 16. 27 This page intentionally left blank 3 Darunavir (Prezista): A HIV-1 Protease Inhibitor for Treatment of Multidrug-Resistant HIV Arun K. Ghosh and Cuthbert D. 1 Ï ^ ( N. ^ ^ ^ ,NH ? Γ iÍJ XJ 0 " *0 USAN: Darunavir 1 Trade name: Prezista® 1 Tibotec Pharmaceuticals 1 Launched: 2006 1 Background Human immunodeficiency virus type 1 (HIV-1) infections continue to be a major global challenge in medicine in the 21st century. l These statistics indicate the magnitude of the global epidemic of HIV/AIDS today.

Opin. Investig. Drugs 2003, 4, 206-209. Rosemond, M. ; Walsh, J. S. Chem. Biol. Interact. 2004,147, 129-139. ; Wai, J. ; Embrey, M. ; Fisher, T. ; Egbertson, M. ; Payne, L. ; Guare, J. P. ; Vacca, J. ; Hazuda, D. ; Felock, P. ; Wolfe, A. ; Stillmock, K. ; Witmer, M. ; Schleif, W. ; Gabryelski, L. ; Leonard, Y. ; Lynch, J. J. ; Michelson, S. ; Young, S. D. J. Med. Chem. 2003, 46, 453-456. Hazuda, D. ; Anthony, N. ; Gomez, R. ; Jolly, S. M ; Wai, J. ; Fisher, T. ; Guare, J. P. ; Egbertson, M. ; Vacca, J.

Egbertson, M. ; Vacca, J. ; Huff, J. ; Felock, P. ; Witmer, M. ; Stillmock, K. ; Miller, M. ; Espeseth, A. ; Chen, I. ; Lin, J. ; Ellis, J. ; Wong, B. ; Pearson, P. ; Schleif, W. ; Holloway, M. ; Young, S. D. Proc. Nati. Acad. Sei. USA 2004,101, 11233-11238. ; Schooley, R. Paper presented at 12th Conference on Retroviruses and Opportunistic Infections, Feb. A. ; Matassa, V. ; Paz, O. ; Pace, P. J. Med. Chem. 2006, 49, 6646-6649. ; Rico Ferreira, M. ; Hommick, C. ; Stillmock, K. ; Summa, V. J.

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Modern Drug Synthesis by Douglas S. Johnson, Jie Jack Li

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