By M. Feitelson
Since the invention of Australia antigen and its organization with variety B hepatitis, molecular characterization of the elements making up hepatitis B virus (RBV) were pursued with around the world curiosity. during the last 20 years, such characterization has resulted in the advance of delicate assays to monitor and exclude infected devices from blood banks and has lately ended in the licensing of numerous RBV vaccines. That greater than two hundred million humans world wide are chronically contaminated with RBV, and they are at a excessive danger for the improvement of continual hepatitis and hepatocellular carcinoma, nonetheless characterize ambitious difficulties in our figuring out of host-virus relationships at the molecular point. within the absence of an acceptable tissue tradition procedure, and with a really constrained host diversity of an infection, characterization of RBV at the molecular point has made amazing development lately with the appearance of genome cloning, sequencing and expression of person virus genes by way of recombinant DNA know-how. The presence of hepatitis B-like viruses in an increasing variety of animal hosts, and the potential for virus replication in cells except hepatocytes, supply nice promise that destiny paintings will elucidate the molecular mechanisms operative within the a variety of results of RBV infection.
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Extra info for Molecular Components of Hepatitis B Virus
Although the glycosylation of p26-29 may be responsible for the differences seen on this level of analysis, the exact relationship of these components to each other requires further investigation. It is interesting to note that the major polypeptide pair of ground squirrel hepatitis surface antigen (GSHsAg (152» and woodchuck hepatitis surface antigen (WHsAg (120», which migrate slightly faster on SDS polyacrylamide gels than the corresponding major HBsAg polypeptide pair, also yielded peptide maps in their respective pairs that shared a large degree of homology (180, 181, 768).
The physical and chemi- cal heterogeneity of HBsAg particles, which is undoubtedly greater in 41 identical experiments, using polyvinylpyrrolidone as control antigen, no differences in the rate of clearance were seen. Since the animals were not primed with either antigen prior to experimentation, it is possible that antibodies cross-reacting with human host components present in HBsAg and/or by macrophages responding to "nonself" determinants on these particles may account for the clearance of HBsAg (and possibly Dane particles) prior to induction of antigen-specific immunity.
And F. Gudat in Progress in Liver Disease, Vol. 4, Chapter 20, pp. 371-392. Copyright 1979 by Grune & Stratton, Inc. (ref. 348)J. immunogenic form, several polypeptide vaccines consisting of p22-25 and p26-29 isolated from preparative SDS gels (351, 352, 355) or by Triton X-lOa treatment of HBsAg particles (350) were used as starting material. Guinea pigs immunized with aqueous polypeptide vaccine yielded antibody titers at least 100 fold less than intact HBsAg under the same conditions and did not show a cell mediated response by inhibition of macrophage migration (352).
Molecular Components of Hepatitis B Virus by M. Feitelson