By Gary Walsh
Pharmaceutical Biotechnology bargains scholars taking Pharmacy and comparable clinical and Pharmaceutical classes a complete advent to the fast-moving sector of biopharmaceuticals. With a specific specialize in the topic taken from a pharmaceutical point of view, preliminary chapters supply a large advent to protein technological know-how and recombinant DNA expertise- key components that underpin the full topic. next chapters concentration upon the improvement, construction and research of those ingredients. ultimately the publication strikes directly to discover the technological know-how, biotechnology and scientific functions of particular biotech items different types. those contain not just protein-based elements but in addition nucleic acid and cell-based items. introduces crucial rules underlining sleek biotechnology- recombinant DNA expertise and protein sciencean priceless creation to this fast-moving topic aimed particularly at pharmacy and scientific studentsincludes particular ‘product classification chapters’ targeting the pharmaceutical, scientific and healing houses of various biopharmaceutical products.entire bankruptcy dedicated to the rules of genetic engineering and the way those medicines are developed.includes a number of correct case experiences to augment scholar understandingno earlier wisdom of protein constitution is believed
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Extra resources for Pharmaceutical Biotechnology: Concepts and Applications
Protein Bioinformatics. Wiley. Fersht, A. 1999. Structure and Mechanism in Protein Science. Freeman. Higgins, D. 2000. Bioinformatics. Oxford University Press. Rehm, H. 2006. Protein Biochemistry and Proteomics. Academic Press. Walsh, C. 2005. Posttranslational Modification of Proteins. Roberts & Company Publishers. , and Honig, B. 2001. Protein structure prediction. Current Opinion in Chemical Biology 5(1), 51–56. Basharov, M. 2003. Protein folding. Journal of Cellular and Molecular Medicine 7(3), 223–237.
2006). Nature Biotechnology 24, 1241–1252 Role/effect Comment Protein folding Glycosylation can effect local protein secondary structure and help direct folding of the polypeptide chain The glycocomponent can participate in the sorting/ directing of a protein to its final destination The carbohydrate content of antibodies, for example, plays a role in antibody binding to monocyte Fc receptors and interaction with complement component C1q The carbohydrate side chain of gonadotrophins is essential to the activation of gonadotrophin signal transduction Sugar side chains can potentially stabilize a glycoprotein in a number of ways, including enhancing its solubility, shielding hydrophobic patches on its surface, protection from proteolysis and by direct participation in intrachain stabilizing interactions High levels of sialic acid (a family of acidic sugars that often caps sugar side chains) can increase a glycoprotein’s plasma half-life.
1 Introduction The biopharmaceutical sector is largely based upon the application of techniques of molecular biology and genetic engineering for the manipulation and production of therapeutic macromolecules. The majority of approved biopharmaceuticals (described from Chapter 8 onwards) are proteins produced in engineered cell lines by recombinant means. Examples include the production of insulin in recombinant E. coli and recombinant S. cerevisiae, as well as the production of EPO in an engineered (Chinese hamster ovary) animal cell line.
Pharmaceutical Biotechnology: Concepts and Applications by Gary Walsh