By Anthony W. Czarnik
The swift enlargement of combinatorial chemistry has renewed curiosity in solid-phase natural synthesis, a mode that lends itself good to making and screening huge numbers of lead compounds. Solid-Phase natural Syntheses, quantity 1 is the 1st quantity in a sequence that might be up to date every year, filling a spot within the latest chemical literature. offering details formerly unavailable from a unmarried source, this sequence is devoted to delivering researchers within the box with proven and proven equipment for the solid-phase synthesis of attention-grabbing and biologically appropriate molecules. Solid-phase equipment will almost regularly be invented for program in combinatorial natural synthesis. to satisfy those particular wishes, Solid-Phase natural Syntheses, quantity 1 specializes in a unmarried kind of man made transformation comprehensive on reliable help, and shows how approaches are optimized to paintings with a structurally-wide number of reagents. Written via famous leaders within the box who evaluate and try all chemical protocols ahead of book, natural adjustments are equipped through form of compound synthesized and response kind. For the 1st time, experimental info for confirmed solid-phase artificial molecules are accumulated in one, priceless source. Solid-Phase natural Syntheses, quantity 1 presents combinatorial chemists and researchers in natural chemistry and medicinal chemistry with the instruments and descriptive protocols to accomplish syntheses of wanted compounds utilizing various sturdy helps and reagents.
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Additional info for Solid-Phase Organic Syntheses, Volume 1
REFERENCES 1. Dax, S. ; McNally, J. ; Youngman, M. A. Curr. Med. Chem. 1999, 6, 251. 2. ; Angiolini, L. , 1994. 3. Youngman, M. ; Dax, S. L. Tetrahedron Lett. 1997, 38, 6347. 1 Experimental Supplement Compound A1. 38). Compound A2. 39). Compound A3. 41). Compound A4. 31). Appendix 51 Compound A5. 41). Compound A6. 51). Compound B1. 53). Compound B2. 53). Compound B3. 55). Compound B4. 46). Compound B5. 56). 52 Solid-Phase Mannich Reactions of a Resin-Immobilized Alkyne Compound B6. 66). Compound C1.
An aliquot (40 mL) of the solution was diluted to 1 mL with 20% piperidine in DMF, and its UV absorption measured at 301 nm. After the supernate was removed by aspiration, the MicroTubes were washed Procedure 19 with DMF, DCM, and MeOH three times. The MicroTubes were dried under vacuum for 24 h after a final washing with ethyl ether. First Amino Acid Coupling A total of 36 MicroTubes ($42 mmol / MicroTube) were sorted into three vials (note 9). ) in DCM (24 mL) for 24 h. After the supernatant was removed by aspiration, the MicroTubes were then washed three times with DMF, DCM, MeOH, and DCM.
Compound A2. 39). Compound A3. 41). Compound A4. 31). Appendix 51 Compound A5. 41). Compound A6. 51). Compound B1. 53). Compound B2. 53). Compound B3. 55). Compound B4. 46). Compound B5. 56). 52 Solid-Phase Mannich Reactions of a Resin-Immobilized Alkyne Compound B6. 66). Compound C1. 48). Compound C2. 49). Compound C3. 51). Compound C4. 41). Compound C5. 51). Compound C6. 61). Compound D1. 51). Appendix 53 Compound D2. 51). Compound D3. 53). Compound D4. 44). Compound D5. 54). Compound D6. 64).
Solid-Phase Organic Syntheses, Volume 1 by Anthony W. Czarnik