Structure, Function and Regulation of TOR complexes from - download pdf or read online

By Fuyuhiko Tamanoi, Michael N Hall

ISBN-10: 0123810051

ISBN-13: 9780123810052

This quantity of The Enzymes gains high-caliber thematic articles concerning glycosylphopshatidylinositol (GPI) anchoring of proteins. * Contributions from top experts * Informs and updates on all of the most recent advancements within the box. summary: positive factors thematic articles related to glycosylphopshatidylinositol (GPI) anchoring of proteins. learn more...

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Additional info for Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part B

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2009). Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem 284:12783–12791. 54. , and Tamanoi, F. (2003). Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J Biol Chem 278:39921–39930. 55. G. (2005). Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett 579:4763–4768. 56. B. (2002). Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells.

The functional differences between Rheb from S. pombe and S. cerevisiae were nicely highlighted by experiments in which expression of human Rheb but not S. cerevisiae Rheb was able to rescue a growtharrest phenotype in Rheb-deficient S. pombe [73]. Therefore, in eukaryotes that lack TSC1 and TSC2 orthologs, such as S. cerevisiae, the relationship between Rheb and TORC1 may be quite different, perhaps suggesting that tight regulation of Rheb by the TSC1–TSC2 complex coevolved with a critical role for Rheb in TORC1 activation.

Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics. J Proteome Res 7:4058–4069. 131. , and Mann, M. (2006). Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127:635–648. 132. D. (2009). Common corruption of the mTOR signaling network in human tumors. Oncogene 27:S43–S51. 133. C. (2005). Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev 19:1773–1778. 134. L.

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Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part B by Fuyuhiko Tamanoi, Michael N Hall


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