New PDF release: The Cell Cycle and Development

By Novartis Foundation

ISBN-10: 0471496626

ISBN-13: 9780471496625

This ebook brings jointly scientists operating on the interface among the phone cycle, phone development and improvement in various version platforms and learn paradigms. the focal point is on realizing how such diversified developmental inputs can modulate cellphone cycle law and, reciprocally, how a standard manner of regulating cellphone cycle development can perform diverse developmental suggestions.

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Example text

In this sense individual growth of the cells may not matter. Gaatzer: Returning to the nuc1ear:cytoplasmic ratio, in a sjtuation where you don’t block any event in the cell cycle, such as experiments in frogs where a mosaic is made between the diploid and tetraploid tissue, the tetraploid cells are twice as large. There is some regulation here: the amount of DNA is somehow influencing the size of the cell. Nurse: I’d like to mention a sort of half-relevant observation in coelocanths, the fish that are living fossils.

In these situations there can thus be disproportionate growth deficiency or overgrowth of organs (Sun et all997, Eggenschwiler et a1 1997, Constkcia 2000, Davies 2000). It is thus likely that there is differential sensitivity of organs to altered overall levels of the growth factor (this may be brought about for example by different receptor concentrations). In addition, local paracrine mechanisms may also play a role particularly when overall levels are drastically altered, as well as in disease situations in which IGFs are abnormally and locally expressed.

Rmyth: Aren’t Purkinje cells the largest cells? Raff: Cardiac myocytes are also very large. E d y r : Can Purkinje cells proliferate as large cells? Raff: No. Most neurons grow after withdrawal from the cell cycle. Motor neurons can become even bigger than Purkinje cells, and they too are clearly diploid. Reik: How significant a phenomenon is cell growth the way you people talk about it in development? If I look at our big mice, their size has little to do with cell enlargement. Schmidt: Are the cells in these mice bigger, or are there more cells?

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The Cell Cycle and Development by Novartis Foundation


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