By M. Michael Wolfe, Gary L., M.D. Davis, Francis A., M.D. Farraye, Ralph, M.D. Giannella
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Influence of the 5-HT1A agonist buspirone on rectal tone and the perception of rectal distension in man. Gastroenterology 1998; 114:G3046. 70. Chial HJ, Camilleri M, Ferber I, et al. Effects of venlafaxine, buspirone and placebo on colonic sensorimotor functions in healthy humans. Clin Gastroenterol Hepatol 2003; 1:211–218. 71. Gorard DA, Libby GW, Farthing MJ. 5-Hydroxytryptamine and human small intestinal motility: effect of inhibiting 5-hydroxytryptamine reuptake. Gut 1994; 35:496–500. 72. Chial HJ, Camilleri M, Burton D, et al.
In a paper published in Science, Lilly and Stillwell8 described probiotics as substances secreted by one microorganism that stimulate the growth of another. The term was mainly applied to animal feed supplements specifically designed to improve health. ’ This definition stressed the importance of viable microbial cells as an essential requirement, and the improvement of the intestinal microbial balance as the mechanism of action. 1 Probiotics and prebiotics improve the symbiotic functions of the gut flora Metabolic effects Lactose digestion Calcium absorption Bowel transit: treatment of constipation Hepatic encephalopathy Production of intestinal gas: irritable bowel syndrome Protective effects Prevention and treatment of gastrointestinal infections Prevention of systemic infections due to bacterial translocation Trophic effects Treatment of inflammatory bowel diseases Prevention and treatment of atopic diseases Prevention of colorectal cancer ficial effect on health or well-being of the host.
Lin HC, Sanders SL, Gu YG, et al. Erythromycin accelerates solid emptying at the expense of gastric sieving. Dig Dis Sci 1994; 39:124–128. 20. Richards RD, Davenport K, McCallum RW. The treatment of idiopathic and diabetic gastroparesis with acute intravenous and chronic oral erythromycin. Am J Gastroenterol 1993; 88:203–207. 21. Otterson MF, Sarna SK. Gastrointestinal motor effects of erythromycin. Am J Physiol 1990; 259:G355–G363. 22. Tack J, Janssens J, Vantrappen G, et al. Effect of erythromycin on gastric motility in controls and in diabetic gastroparesis.
Therapy of Digestive Disorders by M. Michael Wolfe, Gary L., M.D. Davis, Francis A., M.D. Farraye, Ralph, M.D. Giannella